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Recent studies have focused on how the dynamic response of a clean sand changes with increasing fines content; however, there remains a limited understanding regarding the effects of increasing coarse content. This study aims to elucidate these effects at a system level via centrifuge testing of two uniformly-graded and one well-graded soil mixture which range in mean grain diameter (D50) from 0.18 to 2.58 mm and in coefficient of uniformity (CU) from 1.53 to 7.44. Models of each soil mixture were prepared to approximately 50% relative density (DR) and subjected to uniform cycles of sinusoidal acceleration at various Arias intensities (Ia). The high hydraulic conductivity (k) of the coarsest, uniformly-graded mixture prevented significant excess pore pressure generation; however, liquefaction was induced in the other two mixtures. Furthermore, the well-graded mixture exhibited a stronger dilative tendency than the clean sand. The centrifuge results were compared to cyclic direct simple shear (DSS) results in order to consider the complementary perspectives that centrifuge and element testing can provide.